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Monogenic
/ˌmɒn.əˈdʒɛn.ɪk/adjective
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Monogenic refers to traits, diseases, or characteristics that are controlled by a single gene, often following simple inheritance patterns like those described by Mendel. This term highlights the straightforward nature of such genetics in contrast to more complex, multifactorial traits, making it a key concept in modern medical genetics for diagnosing and treating hereditary conditions.
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Cystic fibrosis, a monogenic disorder caused by mutations in a single gene called CFTR, affects about 1 in 2,500 to 3,500 newborns in the United States, and advances in gene therapy are now offering hope for treatments that could correct this defect at the DNA level.
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